List of Publications

Z. Duan, J. Wei, S. B. Carr, M. Ramirez, R. M. Evans, P. A. Ash, P. Rodriguez-Macia*, A. Sachdeva*, and K. A. Vincent*. Cyanophenalalanine as an Infrared Probe for Iron-Sulfur Cluster Redox State in Multi-Centre Metalloenzymes; ChemBioChem, 2025, 10:e2500251. Corresponding author.
 

C. Bernitzky, Y. Rippers, D. Poire, M. Vaithiyanathan, S. L. D. Wrathall, B. Procacci, I. V. Sazanovich, G. M. Greetham, P. Rodríguez-Macía, N. T. Hunt, J. Birrell and M. Horch. Two-dimensional Infrared Spectroscopy Reveals the Vibrational and Molecular Structure of [FeFe] Hydrogenases; Chem. Sci., 2025, 16, 10957-10969
 

A. Depala, M. T. Lachmann, S. Morra, J. A. Birrell and P. Rodriguez-Maciá*. Terminal hydride formation in [FeFe] hydrogenase: understanding the role of the dithiolate bridgehead; Chem. Commun., 2025, 61, 6178-6181. Corresponding author. Highlighted in the 2025 Emerging Investigators collection. This annual special collection showcases research carried out by internationally recognised, up-and-coming scientists in the early stages of their independent careers, and who are making outstanding contributions to their respective fields.
 

P. D. F. Murton, C. R. Timmel, S. R. Mackenzie and P. Rodriguez-Maciá*. Blue-light photodegradation of ferricyanide under protein relevant conditions; Dalton Trans., 2025, 54, 4735-4742. Corresponding author.
 

M. Lachmann, Z. Duan, P. Rodríguez-Maciá* and J. Birrell*. The missing pieces in the catalytic cycle of [FeFe] hydrogenases; Chem. Sci., 2024,15, 14062-14080. Corresponding author.
 

R. Evans, S. Beaton, P. Rodríguez-Maciá, Y. Pang, K. Wong, L. Kertess, W. Meyers, R. Bjornsson, K. Vincent, S. Carr and F. Armstrong. Comprehensive Structural, Infra-red Spectroscopic and Kinetic Investigations of the Role of the active-site Arginine in Bidirectional Hydrogen Activation by the [NiFe]-hydrogenase ‘Hyd-2’ from Escherichia coli; Chem. Sci. 2023,14, 8531-8551
 

N. Chongdar, P. Rodríguez-Maciá, E. Reijerse, W. Lubitz, H. Ogata and J. A. Birrell. Redox tuning of the H-cluster by second coordination sphere amino acids in the sensory [FeFe] hydrogenase from Thermotoga maritima; Chem. Sci. 2023, 14, 3682-3692
 

M. A. Martini*, K. Bikbaev, Y. Pang, C. Lorent, C. Wiemann, N. Breuer, I. Zebger, S. DeBeer, I. Span, R. Bjornsson, J. A. Birrell* and P. Rodríguez-Maciá*. Binding of exogenous cyanide reveals new active-site states in [FeFe] hydrogenases; Chem. Sci. 2023, 14, 2826-2838. Corresponding author.
 

J. Becker, A. Lielpetere, J. Szczesny, J. Junqueira, P. Rodríguez-Maciá, J.  Birrell, F. Conzuelo, W. Schuhmann. Bioelectrocatalytic CO2 Reduction by Redox Polymer Wired Carbon Monoxide Dehydrogenase Gas Diffusion Electrodes; ACS Appl. Mater. Interfaces, 2022, 14, 46421–46426
 

M. Lorenzi, J. Gellett, A. Zamader, M. Senger, Z. Duan, P. Rodríguez-Maciá* and G.Berggren*. Investigating the role of the strong field ligands in [FeFe] hydrogenase: spectroscopic and functional characterization of a semi-synthetic mono-cyanide active site; Chem. Sci. 2022, 13, 11058-11064. Corresponding author. Cover article.
 

M. Lorenzi, P. Ceccaldi, P. Rodríguez-Maciá, H. Redman, Z. Afridi; J. A. Birrell, L. Mészáros, G. Berggren. Stability of the H-cluster under whole-cell conditions – Formation of an Htrans-like state and its reactivity towards oxygen; J. Biol. Inorg. Chem., 2022, 27, 345–355.
 

M. A. Martini, O. Rüdiger, N. Breuer, B. Noering, S. DeBeer, P. Rodríguez-Maciá* and J. A. Birrell*. The non-physiological reductant sodium dithionite and [FeFe] hydrogenase: influence on the enzyme mechanism; J. Am. Chem. Soc. 2021, 143(43), 18159-18171. Corresponding author.
 

J. A. Birrell, P. Rodríguez-Maciá, E. J. Reijerse, M. A. Martini and W. Lubitz. The Catalytic Cycle of [FeFe] Hydrogenase: A Tale of Two Sites, Coord. Chem. Rev. 2021, 449,  214191
 

J. A. Birrell*, P. Rodríguez-Maciá* and Adrian Hery-Barranco. A Beginner’s Guide to Thermodynamic Modelling of [FeFe] Hydrogenase, Catalysts 2021, 11(2), 238. Corresponding author.
 

P. Rodríguez-Maciá*, N. Breuer, S. DeBeer, J. A. Birrell*. Insight into the Redox Behavior of the [4Fe-4S] Subcluster in [FeFe] Hydrogenases, ACS Catal. 2020, 10, 21, 13084–13095. Corresponding author.
 

P. Rodríguez-Maciá, L.M Galle, R. Bjornsson, C. Lorent, I. Zebger, Y. Yoda, S.P Cramer, S. DeBeer, I. Span, J.A Birrell. Caught in the Hinact: Crystal Structure and Spectroscopy Reveal a Sulfur Bound to the Active Site of an O2‐stable State of [FeFe] Hydrogenase; Ang. Chem. Int. Ed. 2020, 38(59), 16786-16794. Highlighted in ChemistryViews.
 

N. Chongdar, K. Pawlak, O. Rüdiger, E. J. Reijerse, P. Rodríguez-Maciá, W. Lubitz, J. A. Birrell, H. Ogata. Spectroscopic and biochemical insight into an electron-bifurcating [FeFe] hydrogenase; J. Biol. Inorg. Chem. 2020, 25, 135–149.
 

P. Rodríguez-Maciá*, L. Kertess, J. Burnik, J. A. Birrell, E. Hofmann, W. Lubitz, T. Happe, O. Rüdiger*. His-Ligation to the [4Fe-4S] Subcluster Tunes the Catalytic Bias of [FeFe] Hydrogenase, J. Am. Chem. Soc. 2019, 141, 472-481. Corresponding author.
 

P. Rodríguez-Maciá, E. J. Reijerse, S. DeBeer, W. Lubitz, O. Rüdiger, J. A. Birrell. Sulfide Protects [FeFe] Hydrogenases From O2, J. Am. Chem. Soc. 2018, 140, 9346–9350. Highlighted in ChemistryViews and Nat. Catal.
 

A. A. Oughli, A. Ruff, N. Priyadarshani-Boralugodage, P. Rodríguez-Maciá, N. Plumeré, W. Lubitz, W. J. Shaw, W. Schuhmann, O. Rüdiger. Dual Properties of a Bio-inspired Ni-catalyst Promoted by a Polymer Matrix as a Case of Self-defense; Nat. Commun. 2018, 9, 864.
 

L. Kertess, A. Adamska-Venkatesh, P. Rodriguez-Maciá, O. Rüdiger, W. Lubitz and T. Happe. Influence of the [4Fe-4S] Cluster Coordinating Cysteines on Active Site Maturation and Catalytic Properties of C. reinhardtii [FeFe]-hydrogenase; Chem. Sci. 2017, 8, 8127 – 8137.
 

V. Engelbrecht, P. Rodríguez-Maciá, J. Esselborn, A. Sawyer, A. Hemschemeier, O. Rüdiger, W. Lubitz, M. Winkler, T. Happe. The Structurally Unique Photosynthetic Chlorella variabilis NC64A Hydrogenase Does Not Interact with Plant-type Ferredoxins; Biochim. Biophys. Acta Bioenerg. 2017 1858, 771 – 778.
 

P. Rodriguez-Maciá, K. Pawlak, O. Rüdiger, E. J. Reijerse, W.Lubitz and J. A. Birrell, Inter-cluster Redox Coupling   Influences Protonation at the H-cluster in [FeFe] Hydrogenases; J. Am. Chem. Soc 2017 139, 15122 – 15134. Cover article.
 

P. Rodríguez-Maciá, E. J. Reijerse, W. Lubitz, J. A. Birrell and O. Rüdiger. Spectroscopic Evidence for Reversible Disassembly of the [FeFe] Hydrogenase Active Site; J. Phys. Chem. Lett. 2017, 8, 3834 – 3839.
 

P. Rodríguez-Maciá, J. A. Birrell, W. Lubitz and O. Rüdiger, Electrochemical Investigations on the Inactivation of the [FeFe]-Hydrogenase from Desulfovibrio desulfuricans by O2 or Light under Hydrogen Producing Conditions; ChemPlusChem 2017, 82, 540 – 545. Cover article.
 

P. Rodríguez-Maciá, N. Priyadarshani, A. Dutta, C. Weidenthaler , W. Lubitz, W. J. Shaw and O. Rüdiger, Covalent Attachment of the Water-insoluble Ni(PCy2NPhe2)2. Electrocatalyst to Electrodes Showing Reversible Catalysis in Aqueous Solution; Electroanalysis 2016, 28, 2452 – 2458
 

J. A. Birrell, K. Wrede, K. Pawlak, P. Rodríguez-Maciá, O. Rüdiger, E. J. Reijerse and W. Lubitz. Artificial Maturation of the Highly Active Heterodimeric [FeFe] Hydrogenase from Desulfovibrio desulfuricans ATCC 7757; Isr. J. Chem. 2016, 56, 852 – 863
 

P. Rodríguez-Maciá, A. Dutta, W. Lubitz, W. J. Shaw and O. Rüdiger. Direct Comparison of the Performance of a Bio-inspired Synthetic Nickel Catalyst and a [NiFe]-Hydrogenase, Both Covalently Attached to Electrodes; Ang. Chem. Int. Ed., 2015 54, 12303 – 12307.